Covid-19 Sentry

Contents

• From Preprints
• From Clinical Trials
• From PubMed
• From Patent Search

From Preprints

• Economic and Social Impacts of Social Entrepreneurship Implementation Service to Community -
  The government’s policy to prevent the spread of COVID-19 has limited physical interaction between communities, creating problems for various everyday economic activities. One of which is the existence of a grant given by the Ministry of Research and Technology / National Innovation Research Agency of the Republic of Indonesia for the implementation of community service by guiding the development of micro?businesses in society. This type of research is a descriptive method with a qualitative approach. Data collection was conducted by interviewing eight informants consisting of recipients of the Family Hope Program assistance. Documentation and observation were also carried out to strengthen the data. Data analysis used an interactive model following Milles and Huberman’s opinion, namely: data reduction, data presentation, and conclusion drawing.
  🖺 Full Text HTML: Economic and Social Impacts of Social Entrepreneurship
  Implementation Service to Community
• Dangers and Strangers: Pathogenic threat, fear, and perceived vulnerability do not predict ethnocentric orientations during the COVID-19 pandemic in Europe. -
  Please refer not to the preprint, but tp the published version (open access!): https://ishe.org/volume-36-2021-2/dangers-and-strangers-pathogenic-threat-fear-and-perceived-vulnerability-do-not- predict-ethnocentric-orientations-during-the-covid-19-pandemic-in-europe/ Previous research has postulated effects of environmental stress on ingroup/outgroup thinking: The higher the pathogenic risk and the perceived vulnerability to it, the higher the ethnocentric orientation. Here, we examine ethnocentric orientations in Austria, Poland, Spain and Czech Republic in spring 2020, as the spread of SARS-CoV2 was on the rise and lockdown measures were introduced throughout Europe. Critically, these countries were affected differentially by the spread of SARS-CoV-2 and COVID-19 mortality. 333 participants were asked to complete questionnaires assessing identification with all humanity, attachment style, and perceived vulnerability to disease at the beginning and end of the first European curfews. Additionally, they answered questions regarding their social interactions and personal consequences of the crisis. To investigate the relationship between these variables and ethnocentrism, we train two types of machine-learning models to predict ethnocentrism based on the complex interplay of interpersonal variables (psychological traits, interpersonal interactions) and environmental conditions (economic threats, local mortality, viral spread, lockdown measures). We find that identification with all humanity in relation to narrower ingroups and perceived infectability did not systematically change over the course of the first European lockdowns, whereas we observe a slight decrease in germ aversion. Importantly, none of our models could predict any inter-individual differences in identification with narrower versus wider groups based on environmental, psychological, social, and demographic variables. Our results indicate that environmental variables connected to pathogenic and economic threat, perceived vulnerability and other psychosocial variables, all do not contribute to predicting ethnocentric orientations. Cumulatively, our results do not support the hypothesis that higher pathogenic and environmental threat predicts identification with narrower ingroups. Our findings are discussed in the context of the open debate related to the influence of harsh environments on group psychology, and might inspire further research on this topic during this unprecedented global pandemic.
  🖺 Full Text HTML: Dangers and Strangers: Pathogenic threat, fear, and perceived vulnerability do not predict ethnocentric orientations during the COVID-19 pandemic in Europe.
• Changes in values and well-being amidst the COVID-19 pandemic in Poland -
  COVID-19 caused a global change in the lifestyles of people around the world. It provided a unique opportunity to examine how external circumstances impact two crucial aspects of functioning relating to “who I am” (values) and “how I feel” (well-being). Participants (N = 150) reported their values, subjective and eduaimonic well-being nine months before lockdown in Poland, two weeks and four weeks into lockdown. We observed significant changes in values: an increase in self-direction, achievement, security, conformity, humility, benevolence and universalism, and a decrease in hedonism. All well-being indices showed a decrease in well-being with one specific difference between men and women: women experienced a more significant increase of negative affect compared to men. Finally, we showed that Openness to change values predict lower negative affect and higher eudaimonic well-being two weeks into lockdown. This study is unique in that it shows, that well-being and individually held values are flexible and adaptive systems that react to external circumstances, such as global critical events.
  🖺 Full Text HTML: Changes in values and well-being amidst the COVID-19 pandemic in Poland
• Architecture Education During the Covid-19 Pandemic -
  Online learning, also known as e-learning, is the result of the evolution of distance learning that has developed following technological developments, especially information technology. Before the pandemic, online learning was only one alternative that enriched the learning process. Various courses are implemented by combining offline and online learning processes called blended learning. Through the Learning Management System (LMS), the Department of Architecture Unhas combines offline and online learning in studio-based design courses. Lecturers and students are trained to carry out the stages of the learning process guided by online procedures. The ongoing Covid-19 pandemic has made online learning the only way to keep the learning process going as planned. The sudden shift of studio-based courses from offline to totally online resulted in a change in the learning environment and experience. This study found that the online learning process is largely determined by the availability of learning materials and instruction in the LMS, the distance between learning space and time, the learning experience and the meaning of independent learning perceived by students. The study involved student participants at all semester levels, academic administration staff, lecturers, and student parents.
  🖺 Full Text HTML: Architecture Education During the Covid-19 Pandemic
• Indonesian Economic Policy Universal Basic Income During the Covid-19 Pandemic for National Defense -
  The impact of the COVID-19 pandemic has prompted the government to carry out social assistance programs. The purpose of this study is to analyze Universal Basic Income as a response to the COVID-19 pandemic which can simultaneously strengthen economic defenses in Indonesia as a form of peace dividends. This research uses the literature study method to previous relevant research strategy theory by identifying ends, ways, and means. The results of this study support universal basic income as a policy (ways) to deal with the crisis due to COVID-19 pandemic. UBI can provide an increase in Indonesia’s economic growth and empower Indonesian people to be better prepared to face risks, which will lead people to innovate more. UBI can also strengthen the defense economy in Indonesia because by reducing poverty, unemployment and social inequality, the crime rate caused by the economy will decrease, human resources will increase, and community relations will be stronger (ends). The resources (Means) needed to implement UBI in Indonesia are the budget, existing regulations, human resources (HR), and the latest Indonesia’s population data.
  🖺 Full Text HTML: Indonesian Economic Policy Universal Basic Income During the Covid-19 Pandemic for National Defense
• Willingness to Take the Booster Vaccine in a Nationally Representative Sample of Danes -
  We estimate the willingness to taking the booster dose in a representative sample of Danes. We estimate an overall willingness in the adult Danish population of 85.5 percent and a willingness of 94.7 percent among primary vaccine takers. We, moreover, show that these percentages will be significantly lower among younger populations as well as among groups who do not see COVID-19 as a threat towards society and who do not perceive the advice of the health authorities as effective against disease spread.
  🖺 Full Text HTML: Willingness to Take the Booster Vaccine in a Nationally Representative Sample of Danes
• Economic and Emotional Perceptions During and After COVID19 -
  Faced with the SARS-CoV-2pandemic, we decided to investigate if recovery from this large exogenous global shock depended on both emotional and economic recovery. We piloted a survey from May 2020 – August 2020 to examine how exposure to this global pandemic shaped economic outlook, and we documented the innate emotional styles of respondents. We then sought to answer two questions. Do the emotional style dimensions have anything to do with economic recovery? And are wages and emotional dimensions associated with economic outlook? With these questions in mind, we estimated two structural equation models. We jointly estimated all six emotional dimensions for the first question and assessed their impact on economic outlook. We estimated a structural model with a Mincer-wage equation and emotional outlook, resilience, and attention equations for the second question. We found that emotional outlook was positively and significantly correlated with economic outlook. We also found that wages, emotional- outlook, resilience, and attention were correlated with returning to behavior-normal, meaning once the public health crisis abates, fear will cease to restrict mobility in all sectors. We found pessimism over returning to business-normal, patronizing businesses that are significantly affected by the pandemic could have a dampening effect on economic recovery. However, this could be offset by the positive correlations between emotional outlook on economic outlook and returning to behavior-normal, both of which could boost economic recovery. From a public policy standpoint fostering a positive emotional outlook and encouraging emotional resilience could be the mojo needed for faster economic recovery.
  🖺 Full Text HTML: Economic and Emotional Perceptions During and After COVID19
• ‘Variant fatigue’? Public attitudes to COVID-19 18 months into the pandemic: A qualitative study -
  Objectives: Qualitative study exploring public attitudes to COVID-19 18 months into the pandemic, specifically focused on adherence to infection-reducing behaviours and policy measures during a period of the emergence of a new variant (Omicron) Study design: Qualitative online focus group study Methods: Focus groups were conducted with a diverse sample of 22 adults in the United Kingdom to explore their views. Data were analysed using a framework approach. Findings: Analysis revealed two main groups based on participants’ perceived concern over Omicron: variant fatigue (n=16 (73%)) and deja vu (n=6 (27%)). Those exhibiting variant fatigue reported not adopting any additional caution or infection-reducing behaviours as a result of the new variant. They tended to describe Omicron as ‘just another variant’ and expressed a need to ‘get on’ and ‘live with’ the virus. Those exhibiting deja vu suggested that Omicron was of additional concern to them and for some posed a threat not seen since ‘last year’ (second wave). No demographic patterns emerged, although there was a high amount of variant fatigue (absence of additional caution) (n=5 (83%)) amongst the unvaccinated participants. Those who were concerned about Omicron tended to report reducing social contacts. Few participants reported taking lateral flow tests regularly, except for those required to by their employers. Stated compliance with facemask rules was high. Nearly all participants stated an intention to comply with any future potential policy measures to reduce transmission of COVID-19, including more stringent measures such as lockdowns. Implications: 18 months into the pandemic, there may be habituation to the risk posed by COVID-19, despite the increased risk posed by the new variant Omicron. Due to this risk habituation (‘variant fatigue’) and due to a general decline in engagement with news related to COVID-19, many people may not be, or might be reluctant to, voluntarily adopt additional caution and infection-reducing behaviours. This poses a challenge for public health communication, since a sense of being ‘relaxed’ about, or ‘living with’ COVID-19 may undermine efforts to encourage voluntary adherence to infection-reducing behaviours. However, findings suggest that most people intend to comply (albeit reluctantly) with policy measures (as opposed to ‘advice’)- including stringent measures such as lockdown - if they were required in future.
  🖺 Full Text HTML: ‘Variant fatigue’? Public attitudes to COVID-19 18 months into the pandemic: A qualitative study
• Agreeableness and neuroticism predict being more concerned about COVID-19 and bothered by friends’ risky behavior -
  Given the importance of friendships during challenging times and the mixed associations reported between personality traits and disease-related behaviors, we investigated the influence of personality traits on friendships during the COVID-19 pandemic and how both influenced risky behaviors. In November 2020, we asked participants about their reactions to friends’ behavior as part of a larger study. We found that agreeableness and neuroticism predicted participants being more concerned about COVID-19 and bothered by friends’ risky behavior, and extraversion predicted enjoying helping friends during the pandemic. Our results suggest that personality influences how individuals cope with their friends’ risky behaviors. This work could be relevant for developing interventions to reduce risk taking during the pandemic, such as using friendships to reinforce adherence to public health guidelines.
  🖺 Full Text HTML: Agreeableness and neuroticism predict being more concerned about COVID-19 and bothered by friends’ risky behavior
• A Moderated Mediation Model of Self-Construal, Social Trust, and Compliance on Covid-19 Public Health Regulation: A Cross-country Analysis -
  To address the global Covid-19 pandemic, governments around the world require on the collective cooperation of their citizens to comply with public health regulation. Earlier studies examined the extent to which self-construal has an impact on individual compliance to law. However, existing literature has paid little significant attention to behavioural outcome of self-construal in the pandemic context across countries and cultures. The aim of this study was;

1. to determine whether interdependent self-construal predicts compliance of Covid-19 public health regulation, 2) to examine if the association was mediated by individual social trust, and 3) to test whether these associations were moderated by respondent’s country of residence (US x Indonesia). General adult respondents from US (N=231) and Indonesia (N=440) were voluntary participated in a survey measuring their trust to the government, interdependent self-construal orientation and compliance toward Covid-19 public health regulation. While our moderated mediation model involving respondent’s country residence did not support the hypothesis, the mediation analysis demonstrated significant association between interdependent self-construal and compliance via social trust. Our additional simple moderation analysis on direct effect of interdependent self-construal and compliance showed significant findings. Further, theoretical and practical implications of these findings were discussed in the following paper.
   🖺 Full Text HTML: A Moderated Mediation Model of Self-Construal, Social Trust, and Compliance on Covid-19 Public Health Regulation: A Cross- country Analysis

• Rapid COVID-19 Test: Investigating the Willingness to Take a Rapid Test Based on Multiple Factors -
  The COVID-19 Pandemic has had a significant impact on society. Due to the large lose of life, scientists have attempted to develop various rapid testing methods. Several methods have been developed among them, an inexpensive paper test. The researcher has endeavored to determine what factors will influence a person’s willing to take a daily covid-19 test. Via a survey instrument that was disseminated we received a response of N=546 participants. We performed many standard statistical tests, t-tests, and one way ANOVA’s as well as Chi Squared tests and Linear by linear associations. Via this analysis were able to determine that there is a statistical significance between willingness to take daily rapid covid-19 test (p <0.05 and, washing your hand (p <0.001), being cautious of your actions (p <0.001), being concerned about covid-19 (p <0.001) and preventing things before they happen (p <0.001). Risk averse people more likely to take preventative measures to take actions to protect themselves and others around them. The lack of basic knowledge regarding the replication of SAR-CoV-2, has led people to underestimate the rapid spread of the virus. Thus, people are coming in contact with others during the most virulent state of the virus.
  🖺 Full Text HTML: Rapid COVID-19 Test: Investigating the Willingness to Take a Rapid Test Based on Multiple Factors
• Epidemic prevention strategies for COVID-19 key populations -
  Abstract Backgroud: Since 2021, all outbreaks of COVID-19 within mainland China have been associated with imported cases from abroad. The outbreak in Putian, Fujian province, occurred without obvious loopholes in the implementation of epidemic prevention, indicating loopholes in the current epidemic prevention strategies in mainland China. The loopholes should be identified and the epidemic prevention strategies should be improved as soon as possible. Methods: Is there a need to further extend the medical observation period and community health surveillance period for key populations? Is there a need to increase the number of nucleic acid screenings? Is there a need to change the methods of extraction of nucleic acid screening samples? Is there a need to expand the scope of the population for routine epidemic prevention surveillance? The analysis of these questions would contribute to the improvement of the COVID-19 epidemic prevention strategies. Results: There are larger outbreaks following the current intensive isolation medical observation period and community health surveillance period, the phenomenon shows that the loopholes in the assessment of cross-infection risk and health surveillance in China’s current COVID-19 prevention and control strategies, especially during health surveillance after the entry of undetected infected individuals into the community when they emerge during isolation medical observation, and during health surveillance in the community for those who regain positive status after case cure. Conclusions: The key points to improve epidemic prevention strategies includ that a scientific and rational assessment around the mean incubation period, cross-infection risk, and surveillance efficiency of COVID-19, and updating routine epidemic prevention surveillance measures for key populations, recently cured patients of COVID-19, and immersion populations. Keywords: COVID-19, epidemic prevention strategy, incubation period, cross-infection
  🖺 Full Text HTML: Epidemic prevention strategies for COVID-19 key populations
• Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study -
  Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 in 2020 (M=2.45) and 2021 (M=2.21) was elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.
  🖺 Full Text HTML: Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study
• Preprints & Pandemics: Interventions into the Dynamic Scholarly System of Scholarly Communication -
  The COVID-19 pandemic is an exemplar of how scholarly communication can change in response to external shocks, even as the scholarly knowledge ecosystem is evolving rapidly, and many argue that swift and fundamental interventions are needed. However, it is much easier to identify ongoing changes and emerging interventions than to understand their immediate and long term impacts. This is illustrated by comparing the approaches applied by the scientific community to understand public health risks and interventions with those applied by the scholarly communications community to the science of COVID-19. There are substantial disagreements over the short- and long- term benefits of most proposed approaches to changing the practice of science communication, and the lack of systematic, empirically-based research in this area makes these controversies difficult to resolve. We argue that the methodology of analysis and intervention developed within public health can be usefully applied to the science-of-science. Starting with the history of DDT application, we illustrate four ways complex human systems threaten reliable predictions and blunt ad-hoc interventions. We then show how these four threats apply lead to the last major intervention in scholarly publication – the article publishing charge based open access model – to yield surprising results. Finally, we outline how these four threats may affect the impact of preprint initiatives, and we identify approaches drawn from public health to mitigate these threats.
  🖺 Full Text HTML: Preprints & Pandemics: Interventions into the Dynamic Scholarly System of Scholarly Communication
• Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response -
  A damaging inflammatory response is strongly implicated in the pathogenesis of severe COVID-19 but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated, anti-SARS- CoV-2 IgG predicted progression from mild, to more severe COVID-19. In contrast to the antibody structures that predicted disease progression, antibodies that were elicited by mRNA SARS-CoV-2 vaccines were low in Fc afucosylation and enriched in sialylation, both modifications that reduce the inflammatory potential of IgG. To study the biology afucosylated IgG immune complexes, we developed an in vivo model which revealed that human IgG-Fc{gamma}R interactions can regulate inflammation in the lung. Afucosylated IgG immune complexes induced inflammatory cytokine production and robust infiltration of the lung by immune cells. By contrast, vaccine elicited IgG did not promote an inflammatory lung response. Here, we show that IgG-Fc{gamma}R interactions can regulate inflammation in the lung and define distinct lung activities associated with the IgG that predict severe COVID-19 and protection against SARS-CoV-2.
  🖺 Full Text HTML: Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

From Clinical Trials

• Phase III Study of Novaferon in Non-hospitalized Adult Patients With Mild COVID-19 - Condition:   Covid19
  Interventions:   Biological: Novaferon;   Biological: Placebo
  Sponsors:   Genova Inc.;   Tokyo Shinagawa Hospital
  Recruiting

• Quality of Life and Lung Function on Post Covid-19 Patient - Condition:   COVID-19
  Intervention:   Other: breathing exercise, Aerobic exercises
  Sponsor:   Qassim University
  Recruiting

• A Safety, Tolerability, and Efficacy Study of IBI314 in Ambulatory Patients With COVID-19 - Condition:   COVID-19
  Interventions:   Biological: IBI314;   Other: Placebo
  Sponsor:   Innovent Biologics (Suzhou) Co. Ltd.
  Not yet recruiting

• A Safety, Tolerability, and Efficacy Study of IBI314 in Mild to Moderate Patients With COVID-19 - Condition:   COVID-19
  Interventions:   Biological: IBI314(low dose);   Biological: IBI314(high dose);   Biological: IBI314(medium dose);   Other: Placebo
  Sponsor:  
  Innovent Biologics (Suzhou) Co. Ltd.
  Not yet recruiting

• Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19 - Condition:   COVID-19
  Interventions:   Drug: Belnacasan;   Drug: Placebo
  Sponsor:  
  MedStar Health
  Recruiting

• A Study Evaluating Tocilizumab in Pediatric Patients Hospitalized With COVID-19 - Condition:   COVID-19
  Intervention:   Drug: Tocilizumab
  Sponsor:   Hoffmann- La Roche
  Not yet recruiting

• Safety and Immunogenicity Study of Booster Vaccination in Different Doses of COVID-19 Vaccine (Vero Cell),Inactivated for Prevention of COVID-19 - Condition:   COVID-19
  Interventions:   Biological: High-dosage of COVID-19 vaccine (Vero cell), Inactivated;   Biological: Medium-dose COVID-19 Vaccine(Vero Cell),Inactivated
  Sponsor:  
  Sinovac Research and Development Co., Ltd.
  Active, not recruiting

• Safety and Immunogenicity Study of Booster Vaccination With COVID-19 Vaccine (Vero Cell),Inactivated From Different Manufactures for Prevention of COVID-19 - Condition:   COVID-19
  Interventions:   Biological: Experimental vaccine 1;   Biological: Experimental vaccine 2;   Biological: Experimental vaccine 3
  Sponsor:  
  Sinovac Research and Development Co., Ltd.
  Not yet recruiting

• Combination Assessment Trial of COVID-19 Vaccines (COMBAT-COVID) - Condition:   COVID 19 Vaccine
  Interventions:   Biological: BIBP (CNBG, Sinopharm) WIV;   Biological: CanSinoBIO;   Biological: AstraZeneca ChAdOx
  Sponsors:  
  Aga Khan University Hospital, Pakistan;   Coalition for Epidemic Preparedness Innovations;   University of Oxford;   International Vaccine Institute;   Harvard Medical School (HMS and HSDM);   Chughtai Lab;   National Institute of Health, Pakistan
  Not yet recruiting

• Oral Neutralizing Antibody Booster for Post-vaccinated People With COVID19 Vaccine - Condition:   COVID-19 Pandemic
  Intervention:   Dietary Supplement: Bacillus subtilis spore extract
  Sponsors:   DreamTec Research Limited;   Hong Kong Metropolitan University;   DreamTec Cytokine Limited
  Recruiting

• Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail - Conditions:   COVID-19;   Organ Transplant
  Intervention:  
  Drug: Casirivimab and Imdevimab Antibody Cocktail
  Sponsors:   Northwell Health;   Regeneron Pharmaceuticals
  Not yet recruiting

• Use of Low-frequency Magnetic Fields in the Hybrid Treatment of COVID-19 Patients - Conditions:   COVID-19;   COVID-19 Respiratory Infection;   COVID-19 Pneumonia
  Intervention:  
  Other: magnetostimulation
  Sponsor:   Medical University of Lodz
  Active, not recruiting

• CONFIDENT: Supporting Long-term Care Workers During COVID-19 - Conditions:   COVID-19 Pandemic;   COVID-19 Vaccine Confidence
  Interventions:  
  Behavioral: Dialogue-Based Webinar;   Behavioral: Social Media Website;   Other: Enhanced Usual Practice
  Sponsors:   Dartmouth-Hitchcock Medical Center;   National Association of Health Care Assistants;   Institute for Healthcare Improvement;   East Carolina University
  Not yet recruiting

• Severity of COVID-19 and Vitamin D Supplementation - Condition:   COVID-19 Respiratory Infection
  Intervention:   Drug: vitamin D
  Sponsor:   Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
  Active, not recruiting

• A Study to Evaluate the Ability of UB-612 COVID-19 Vaccine to Boost Immunity of Heterologous COVID-19 Vaccines. - Condition:   COVID-19; SARS-CoV-2
  Intervention:   Biological: UB-612
  Sponsor:  
  United Biomedical Inc., Asia
  Not yet recruiting

From PubMed

• Human mesenchymal stem cells treatment for severe COVID-19: 1-year follow-up results of a randomized, double-blind, placebo-controlled trial - BACKGROUND: The long-term consequences of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment for COVID-19 patients are yet to be reported. This study assessed the 1-year outcomes in patients with severe COVID-19, who were recruited in our previous UC-MSC clinical trial.

• Colchicine use in patients with COVID-19: A systematic review and meta-analysis - CONCLUSION: Colchicine may reduce the risk of mortality in individuals with COVID-19. Further prospective investigation may further determine the efficacy of colchicine as treatment in COVID-19 patients in various care settings of the disease, including post-hospitalization and long-term care.

• A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets - Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged-Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-demonstrating that coronaviruses (CoVs) pose a serious threat to human health and highlighting the importance of developing effective therapies against them. Similar to other viruses, CoVs are dependent on host factors…

• Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation - The pharmacological arsenal against the COVID-19 pandemic is largely based on generic anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing vaccination campaign is rolling slower than wished, affordable and effective therapeutics are needed. To this end, there is increasing attention toward computational methods for drug repositioning and de novo drug design. Here, multiple data-driven computational approaches are systematically integrated to perform a virtual…

• Investigation of small molecule inhibitors of the SARS-CoV-2 papain-like protease by all-atom microsecond modelling, PELE Monte Carlo simulations, and in vitro activity inhibition - The SARS-CoV-2 papain-like (PL^(pro)) protease is essential for viral replication. We investigated potential antiviral effects of hypericin relative to the well-known noncovalent PL^(pro) inhibitor GRL-0617. Molecular dynamics and PELE Monte Carlo simulations highlight favourable binding of hypericin and GRL-0617 to the naphthalene binding pocket of PL^(pro). Although not potent as GRL-0617 (45.8 vs 1.6µM for protease activity, respectively), in vitro fluorogenic enzymatic assays with hypericin…

• Inhibiting TGF-[Formula: see text] 1-Mediated Cellular Processes as an Effective Strategy for the Treatment of Pulmonary Fibrosis with Chinese Herbal Medicines - Pulmonary fibrosis (PF) is a chronic and irreversible interstitial lung disease that even threatens the lives of some patients infected with COVID-19. PF is a multicellular pathological process, including the initial injuries of epithelial cells, recruitment of inflammatory cells, epithelial-mesenchymal transition, activation and differentiation of fibroblasts, etc. TGF-[Formula: see text]1 acts as a key effect factor that participates in these cellular processes of PF. Recently, much attention…

• Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro - Phytochemicals with potential to competitively bind to the host receptors or inhibit SARS-CoV-2 replication, may prove to be useful as adjunct therapeutics for COVID-19. We profiled and investigated the phytochemicals of Rhododendron arboreum petals sourced from Himalayan flora, undertook in vitro studies and found it as a promising candidate against SARS-CoV-2. The phytochemicals were reported in various scientific investigations to act against a range of virus in vitro and in vivo, which…

• Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review - Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome…

• Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model - The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols…

• Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro - Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and high mortality, resulting in tremendous damages to the swine industry. Neither specific antiviral drugs nor effective vaccines are available, posing a high priority to screen antiviral drugs. The aim of this study is to investigate anti-PEDV effects of carbazole alkaloid derivatives. Eighteen carbazole…

• SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response - In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections. Although coronaviruses are known to utilize the transport of autophagy-dependent vesicles for the viral life cycle, the underlying autophagy-inducing mechanisms remain largely unexplored. Using several autophagy-deficient cell lines and autophagy inhibitors, we demonstrated that SARS-CoV-2 ORF3a was able…

• Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro - Epidemic RNA viruses seem to arise year after year leading to countless infections and devastating disease. SARS-CoV-2 is the most recent of these viruses, but there will undoubtedly be more to come. While effective SARS-CoV-2 vaccines are being deployed, one approach that is still missing is effective antivirals that can be used at the onset of infections and therefore prevent pandemics. Here, we screened FDA-approved compounds against SARS-CoV-2. We found that atovaquone, a pyrimidine…

• Soliris to Stop Immune-Mediated Death in COVID-19 (SOLID-C19)-A Compassionate-Use Study of Terminal Complement Blockade in Critically Ill Patients with COVID-19-Related Adult Respiratory Distress Syndrome - Eculizumab, a terminal complement (C5)-inhibiting monoclonal antibody, was administered in five mechanically ventilated patients in life-threatening condition due to COVID-19-related acute respiratory distress syndrome (ARDS) between 23 March 2020 and 3 April 2020. Their clinical progress was monitored. The primary endpoint was mortality. One patient was excluded while two passed away. The remaining two patients survived. At the time of this study, the mortality rate in mechanically ventilated…

• Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection - Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and necroptosis of infected cells, especially in the murine macrophages. However, whether ferroptosis, a recently identified form of lytic cell death, was involved in the pathogenicity of MHV-A59 is unknown. We utilized murine macrophages and a C57BL/6 mice intranasal infection model to address this. In primary macrophages, the ferroptosis inhibitor inhibited viral propagation, inflammatory cytokines released,…

• Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread - The ongoing coronavirus disease (COVID-19) pandemic has required a variety of non-medical interventions to limit the transmission of the causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One such option is over-the-counter nasal sprays that aim to block virus entry and transmission within the nasal cavity. In this study, we assessed the ability of three hydroxypropyl methylcellulose (HPMC)-based powder nasal sprays, produced by Nasaleze, to inhibit SARS-CoV-2…

From Patent Search

• Hung Thanh Phan COVID-19 NEW SOLUTION - - link

• METHODS OF TREATING SARS-COV-2 INFECTION - - link

• REAL-TIME REST BREAK MANAGEMENT SYSTEM FOR WORKPLACE - The present invention relates to a real-time rest break management system for workplace that comprises of a work desk, wherein first portion is incorporated with a biometric unit 4 for authenticating first user, and a second portion with a telescopic panel 2 associated with a weight sensor 6 and timer unit 7 calculating weight of head/hand manifesting user presence and their resting time period is mounted with an inflated cushion 5, an interactive primary display unit 1 attached over desk enables user to set first/second threshold time for sleeping/taking break, further linked with a tracking interface keeping track of activities and a vibrating unit crafted inside the cushion 5 which is linked to a secondary display unit 8 of second user, giving them access to actuate vibrating unit generating impulses to wake first user when threshold time period is exceeded by the first user. - link

• P2P 네트워크를 이용한 내장된 화상회의 시스템 - 본 발명은 P2P 네트워크를 이용한 내장된 화상회의 시스템에 관한 것으로, 상태표시부(1), 영상송출부(2), 제어부(3), 광고부(4), 입력부(5)를 포함한다. - link

• 小分子化合物肌醇六磷酸酯钠水合物在制备抗SARS-CoV-2药物中的应用 - 本发明公开了小分子化合物肌醇六磷酸酯钠水合物在制备抗严重急性呼吸综合征冠状病毒2(SARS‑CoV‑2)药物中的应用，所述抗SARS‑CoV‑2药物是以肌醇六磷酸酯钠水合物为唯一的活性成份，或包含肌醇六磷酸酯钠水合物的药物组合物，所述抗SARS‑CoV‑2药物是指预防或治疗SARS‑CoV‑2感染的药物。本发明利用SARS‑CoV‑2的易感细胞系，包括非洲绿猴肾细胞Vero

E6以及人肺腺癌细胞Calu‑3，检测肌醇六磷酸酯钠水合物的抗SARS‑CoV‑2活性。实验结果显示，肌醇六磷酸酯钠水合物能有效抑制SARS‑CoV‑2对上述易感细胞的感染，且细胞毒性较小，有希望作为有效抗SARS‑CoV‑2感染的药物，具有应用前景。 - link

• A DOORBELL SYSTEM FOR MONITORING AND RECORDING A PHYSIOLOGICAL DATA OF A PERSON - AbstractTitle: A doorbell system for monitoring and recording a physiological data of a person The present invention provides a doorbell system 500 for monitoring and recording a physiological data of a person. The doorbell system 500 having a transmitter module 100 and a receiving module 200. The transmitter module 100 is having a TOF sensor module 110, an ultrasound detector 120, and an infrared detector 130. Further, a speech recognition system 150, a facial recognition system 160, and a temperature detector 190 are provided for recognizing speech, face, and temperature of the person by comparing pre-stored data. A controlling module 180 is set with a predefined commands for communicating with the transmitter module 100 and receiving module 200. The collected facial and speech data is compared and matched with the pre-stored data then the temperature detector 190 triggers and the door opens when the captured body temperature of the person is matched within the predefined range of temperature.Figure 1 - link

• Schnelltestsystem -

  Schnelltestsystem, aufweisend: eine Testkassette (11), die ein Testfeld (111) und einen einem bestimmten Benutzer entsprechenden Identifikationsstrichcode (113) aufweist, wobei das Testfeld (111) eine Probe (115) empfängt, um eine Testreaktion (R) zu bewirken, wodurch sich ein der Testreaktion (R) entsprechendes Muster (G) ergibt; und ein tragbares elektronisches Gerät (13), das eine Bildaufnahmeeinheit (131) aufweist, wobei die Bildaufnahmeeinheit (131) das Muster

7. und den Identifikationsstrichcode (113) liest und anschließend an einen Server (15) sendet.

• link

• A study of contemporary trends in investing patterns, household savings, and economic investment. - Because household savings and household investments are intertwined and interdependent, they are discussed briefly in this paper. Household savings account for more than half of a country’s capital formation, which fluctuates due to a variety of economic factors such as inflation and interest rates. Households should gradually shift their savings and investments from physical assets to financial assets to avoid a sudden change in wealth. They should also save and invest using a variety of platforms. Trends in investing and saving will be easier to track and measure this way. This year’s domestic saving rate in India is 2.3 percent lower than last year’s and 1.2 percent lower than the year before. Since 2011, general domestic savings have been steadily declining, with the trend continuing into the following year. According to official data, the GDP in 2020 shrank by 23.9%, the least in previous years and the least since the Covid-19 pandemic in previous years. As a result, the information presented in this paper is drawn from and evaluated from other sources - link

• 靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗 - 本发明公开了一种靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗。本申请的第一方面提供一种分离的DNA分子组合，该DNA分子组合包括第一DNA分子和第二DNA分子和第三DNA分子中的至少一种。通过第一DNA分子以及第二DNA分子和/或第三DNA分子的组合，利用第一DNA分子最终合成的mRNA诱导高滴度的交叉中和抗体，利用第二DNA分子和/或第三DNA分子最终合成的mRNA诱导新冠病毒特异性的细胞毒性T淋巴细胞，从而高效地同时激活相对独立的体液免疫应答和细胞免疫应答，应对新冠病毒在流行传播过程中产生的突变毒株所引发的突破性感染。 - link

• 跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途 - 本发明公开了跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途。本发明通过亲和垂钓及活性导向分离获得3种化合物，证实该类化合物可以直接地与跨膜丝氨酸蛋白酶2结合，KD<13μM，且能够显著抑制跨膜丝氨酸蛋白酶2的催化活性。在细胞水平上可以有效的抑制新型冠状病毒SARS‑CoV‑2假病毒入侵，表明该类化合物对于制备治疗和/或预防病毒感染药物具有非常积极的作用。化合物1 化合物2 化合物3。 - link